Tianjin University (TJU)
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Introduction to Tianjin University
Founded in 1895 as Peiyang University, Tianjin University (TJU) is the first university in China. As the pioneer of modern higher education in China, TJU has been committed to the mission of revitalizing this country through education ever since its foundation. About Tianjin University Tianjin University, previously known as Peiyang University, was the first modern university in China. Since it was established in 1895, it has been an academic leader in research and teaching, living up to the university motto of “Seeking Truth from Facts”. The university was renamed Tianjin University (TJU) in 1951. In 1959, it became one of the first National Key Universities and in later years was among the first group of universities to be included in the “211” and “985” projects which aim at developing world-class universities. TJU is equipped with experienced faculty and has distinctive disciplinary features. It is committed to constantly improving its education quality and level of scientific research in an effort to maintain its position as a world-class institution. The University welcomed its first batch of international students in 1954. Home to more than 20,000 international students from 120 countries/regions, TJU has become one of the best universities to study in China. About School of International Education (SIE) Tianjin University school of International Education was established in January 2000, it is one of the secondary schools of Tianjin University. The school of International Educational takes enrollment, teaching administration, social administration and services functions of international students at Tianjin University for its main task, and also undertakes the Chinese language teaching for international students. At present, Tianjin University has formed various types and levels in international student education including short-term and long-term Chinese language courses, undergraduate, master degree to Ph. D students. There are 42 countries students are studying at this university now, compared with that of 20 years ago, only 10 countries students studied here. Along with increases of international students and their countries, there has formed a multi-culture and internationalization atmosphere on campus. Location Situated in the heart of Tianjin City, one of the four municipalities directly under the Central Government of China, the University offers an unrivalled student experience in a thriving, cosmopolitan community which will set the scene for the rest of your life. Known as a microcosm of modern China, Tianjin has been selected as the best commercial city and the most creative city in mainland China, also one of top ten Charming Tourist City in the nation. About 120 kilometers away or 30 minutes by inter-city express train from Beijing, Capital of China, Tianjin enjoys the convenience as Beijing’s neighbor, and much lower cost of living compared with other cities in its category, such as Shanghai and Beijing. Job Offers and Internship Opportunities As the permanent host city of the Summer Davos Forum, Tianjin is now an economic center, the largest international port city and the eco city in Northern China. With the national strategies of Tianjin Binhai New Area, Beijing-Tianjin-Hebei integration and Tianjin Free Trade Zone, a number of leading companies have their branches, R&D centers or even headquarters in Tianjin, which bring plenty of job offers and internship opportunities. Living in University TJU has one of the most active on-campus communities in China. A variety of extracurricular activities are offered through dozens of student groups and organizations such as Peiyang Arts Troupe, Youth Volunteer Association and many other clubs around campus. They offer social events such as the Weekend Concert, Robot Festival and so on. The campus provides a unique and supportive environment in which students can learn and grow while enjoying the campus life. There are many sports fitness place in Tianjin University. For example, student activity center, stadium, gymnasium, swimming pool, tennis court, badminton court and table tennis hall etc. Students can access these places with their Student ID Card. And they have to pay the relevant expenses.
Tianjin University develops customized synthetic microbial cell factory
| Updated: 2017-12-19 16:43:09 | (exploringtianjin.com) | A team led by Zhao Guangrong, a professor of Tianjin University (TJU), established an artificial biosynthetic pathway to produce salvianic acid A in an engineered bacterial fermentation process. Results of the breakthrough were published in Metabolic Engineering and Microbial Cell Factories, two well renowned biotechnology journals. The invention patents were authorized by the State Intellectual Property Office of China. Salvianic acid A, a drug with the active pharmacological properties of improving cerebral blood flow, inhibiting platelet activation and arterial thrombosis, is used to treat cardiovascular diseases. Salvianic acid A is now prepared from the plant Salvia miltiorrhiza root, but has low yield and unreliable quality. Salvianic acid A is extracted from Salvia miltiorrhiza root in China. The traditional method of water extraction followed by alcohol precipitation led to excessive concentration of alcohol and loss of phenolic constituents including salvianic acid A. More recent preparation methods including enzymatic and microwave extraction have not resolved crucial problems such as limited plant material, unreliable quality and low productivity as well as the seasonal and geographical constraints of growing Salvia miltiorrhiza. Although full synthesis of the natural product is considered to improve the quantity and quality of the derived medical products, the chemical synthesis of salvianic acid A was troubled by complex procedures, poor stereoselectivity, low yield and was an unfriendly environmental impact. Professor Zhao's team developed the artificial biosynthesis of salvianic acid A. Guided by catalytic mechanisms of bio-enzymes and retrosynthetic analysis and by mining big bioinformation databases, the team discovered that a P450 enzyme can hydroxylate by meta-position hydroxyphenylpyruvic acid, the precursor of salvianic acid A. A D-lactic dehydrogenase can reduce keto in the hydroxyl group, which generates salvianic acid A. The team recombined and reassembled genetic modules for synthetizing hydroxyphenylpyruvic acid and attained Escherichia coli cells as chassis to mass produce the precursor. Then they introduced the module of salvianic acid A synthetic genes into the chassis cell, and established the artificial biosynthesis of salvianic acid A from glucose. The customized synthetic microbial cell factory produced salvianic acid A is above 7g/L. Nature Chemical Biology, a Nature journal, highlighted the team's research and pointed out that "this artificial route provides a new source for a plant polyphenols". The team recently modified the genome by precisely integrating the genetic modules of biosynthetic salvianic acid A and the enhanced precursor supply onto a chromosome of Escherichia coli. Meanwhile, they deleted junk genes so that engineered Escherichia coli was more efficient as a microbial cell factory. Thus, salvianic acid A could be continually synthesized without additional use of antibiotics and fermentation inducers. The project was supported by the National Basic Research Program of China, the National High-Tech R&D Program of China, and the Natural Science Foundations of China and Tianjin. Nowadays, synthetic biology has become a powerful engine for the development of green bio-manufacturing. This next generation of biotechnology promises to solve major issues of resource and energy depletion, healthcare, the environment and security by reshaping the traditional biotech industry. Zhao's research is one excellent example of the customized production of medicines and valuable chemicals by decreasing dependency on natural resources.
Tianjin University develops customized synthetic microbial cell factory
| Updated: 2017-12-19 16:43:09 | (exploringtianjin.com) | A team led by Zhao Guangrong, a professor of Tianjin University (TJU), established an artificial biosynthetic pathway to produce salvianic acid A in an engineered bacterial fermentation process. Results of the breakthrough were published in Metabolic Engineering and Microbial Cell Factories, two well renowned biotechnology journals. The invention patents were authorized by the State Intellectual Property Office of China. Salvianic acid A, a drug with the active pharmacological properties of improving cerebral blood flow, inhibiting platelet activation and arterial thrombosis, is used to treat cardiovascular diseases. Salvianic acid A is now prepared from the plant Salvia miltiorrhiza root, but has low yield and unreliable quality. Salvianic acid A is extracted from Salvia miltiorrhiza root in China. The traditional method of water extraction followed by alcohol precipitation led to excessive concentration of alcohol and loss of phenolic constituents including salvianic acid A. More recent preparation methods including enzymatic and microwave extraction have not resolved crucial problems such as limited plant material, unreliable quality and low productivity as well as the seasonal and geographical constraints of growing Salvia miltiorrhiza. Although full synthesis of the natural product is considered to improve the quantity and quality of the derived medical products, the chemical synthesis of salvianic acid A was troubled by complex procedures, poor stereoselectivity, low yield and was an unfriendly environmental impact. Professor Zhao's team developed the artificial biosynthesis of salvianic acid A. Guided by catalytic mechanisms of bio-enzymes and retrosynthetic analysis and by mining big bioinformation databases, the team discovered that a P450 enzyme can hydroxylate by meta-position hydroxyphenylpyruvic acid, the precursor of salvianic acid A. A D-lactic dehydrogenase can reduce keto in the hydroxyl group, which generates salvianic acid A. The team recombined and reassembled genetic modules for synthetizing hydroxyphenylpyruvic acid and attained Escherichia coli cells as chassis to mass produce the precursor. Then they introduced the module of salvianic acid A synthetic genes into the chassis cell, and established the artificial biosynthesis of salvianic acid A from glucose. The customized synthetic microbial cell factory produced salvianic acid A is above 7g/L. Nature Chemical Biology, a Nature journal, highlighted the team's research and pointed out that "this artificial route provides a new source for a plant polyphenols". The team recently modified the genome by precisely integrating the genetic modules of biosynthetic salvianic acid A and the enhanced precursor supply onto a chromosome of Escherichia coli. Meanwhile, they deleted junk genes so that engineered Escherichia coli was more efficient as a microbial cell factory. Thus, salvianic acid A could be continually synthesized without additional use of antibiotics and fermentation inducers. The project was supported by the National Basic Research Program of China, the National High-Tech R&D Program of China, and the Natural Science Foundations of China and Tianjin. Nowadays, synthetic biology has become a powerful engine for the development of green bio-manufacturing. This next generation of biotechnology promises to solve major issues of resource and energy depletion, healthcare, the environment and security by reshaping the traditional biotech industry. Zhao's research is one excellent example of the customized production of medicines and valuable chemicals by decreasing dependency on natural resources.
Knowledge Graph
Examples
1 Tianjin University occupies an area of 1.37 km2, and has a built-up area of 800,000 m2, including the two modern libraries, with a total floor space of 26,000 m2 and a collection of 2 million volumes.
2 Tianjin University occupies an area of 1.37 km2, and has a built-up area of 800,000 m2, including the two modern libraries, with a total floor space of 26,000 m2 and a collection of 2 million volumes.
3 Tianjin University boasts a strong team of professional and concurrent researchers.
4 Tianjin University boasts a strong team of professional and concurrent researchers.
5 Tianjin University is a key university in China, one of China’s first group of key universities of "Project 211" and "Project 985".
6 Tianjin University occupies an area of 1.37 km2, and has a built-up area of 800,000 m2, including the two modern libraries, with a total floor space of 26,000 m2 and a collection of 2 million volumes.
7 Tianjin University boasts a strong team of professional and concurrent researchers.
8 Tianjin University is a key university in China, one of China’s first group of key universities of "Project 211" and "Project 985".
9 Tianjin University boasts a strong team of professional and concurrent researchers.
10 Tianjin University is a key university in China, one of China’s first group of key universities of "Project 211" and "Project 985".
11 Tianjin University is a key university in China, one of China’s first group of key universities of "Project 211" and "Project 985".
12 Tianjin University occupies an area of 1.37 km2, and has a built-up area of 800,000 m2, including the two modern libraries, with a total floor space of 26,000 m2 and a collection of 2 million volumes.
13 Tianjin University is a key university in China, one of China’s first group of key universities of "Project 211" and "Project 985".
14 Tianjin University occupies an area of 1.37 km2, and has a built-up area of 800,000 m2, including the two modern libraries, with a total floor space of 26,000 m2 and a collection of 2 million volumes.
15 Tianjin University boasts a strong team of professional and concurrent researchers.