Xi'an Jiaotong University (XJTU)
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Chinese, French scientists develop a one-two punch for cancer treatment
Chinese and French scientists found a potential way using tiny gas bubbles induced by exposure to ultrasonic waves to at once deliver drug and block tumor growth. In a study published on Tuesday in the journal Applied Physics Letters, scientists from Xi'an Jiaotong University in China and University of Tours in France discovered the dual use of gas embolotherapy, a therapy that cuts off the blood vessels that feed tissue growth by acoustic droplet vaporization (ADV). ADV uses microscopic gas bubbles induced by exposure to ultrasonic waves, according to the researchers. This method of starving tumors of blood supply and nutrients is less invasive than surgery. "We have found that gas embolotherapy has great potential to not only starve tumors by shutting off blood flow, but also to be used as a source of targeted drug delivery," said Feng Yi, associate professor of biomedical engineering at Xi'an Jiaotong University and first co-author of the paper. In gas embolotherapy, researchers inject droplets, from tens to hundreds of nanometers in diameter, into feeder vessels surrounding the tumor and then thanks to the ultrasound, the droplets become gas bubbles that can block feeder vessels like arterioles. The researchers found that the bubbles not only blocked the arterioles, but other gas bubbles made their way into the capillaries, resulting in vessel rupture. Researchers tested ex vivo on rat tissue that attaches the intestines to the abdominal wall. They delivered droplets of dodecafluoropentane containing a bovine serum. With the ultrasound, the bubbles accumulated, sometimes merging, as they lodged themselves in the capillaries. At one point, the researchers observed a local vessel invagination or a pouchlike cavity, which was caused by the interaction between the bubble and vessel and led to a capillary rupture. Their findings could provide a one-two punch for cancer treatment: shutting off blood flow from the arterioles and delivering drugs through the capillaries. In addition, chemotherapy drugs could be kept localized for longer periods of time because blood flow has been shut down, reducing drug dosage. "In cancer therapy research, scientists are always interested in answering two questions: how to kill the cancer effectively and how to reduce the side effects of chemotherapeutic drugs," said Wan Mingxi, professor of biomedical engineering also at Xi'an Jiaotong University and corresponding author of the paper. "We have found that gas embolotherapy has the potential to successfully address both of these areas," said Wan.
Chinese, French scientists develop a one-two punch for cancer treatment
Chinese and French scientists found a potential way using tiny gas bubbles induced by exposure to ultrasonic waves to at once deliver drug and block tumor growth. In a study published on Tuesday in the journal Applied Physics Letters, scientists from Xi'an Jiaotong University in China and University of Tours in France discovered the dual use of gas embolotherapy, a therapy that cuts off the blood vessels that feed tissue growth by acoustic droplet vaporization (ADV). ADV uses microscopic gas bubbles induced by exposure to ultrasonic waves, according to the researchers. This method of starving tumors of blood supply and nutrients is less invasive than surgery. "We have found that gas embolotherapy has great potential to not only starve tumors by shutting off blood flow, but also to be used as a source of targeted drug delivery," said Feng Yi, associate professor of biomedical engineering at Xi'an Jiaotong University and first co-author of the paper. In gas embolotherapy, researchers inject droplets, from tens to hundreds of nanometers in diameter, into feeder vessels surrounding the tumor and then thanks to the ultrasound, the droplets become gas bubbles that can block feeder vessels like arterioles. The researchers found that the bubbles not only blocked the arterioles, but other gas bubbles made their way into the capillaries, resulting in vessel rupture. Researchers tested ex vivo on rat tissue that attaches the intestines to the abdominal wall. They delivered droplets of dodecafluoropentane containing a bovine serum. With the ultrasound, the bubbles accumulated, sometimes merging, as they lodged themselves in the capillaries. At one point, the researchers observed a local vessel invagination or a pouchlike cavity, which was caused by the interaction between the bubble and vessel and led to a capillary rupture. Their findings could provide a one-two punch for cancer treatment: shutting off blood flow from the arterioles and delivering drugs through the capillaries. In addition, chemotherapy drugs could be kept localized for longer periods of time because blood flow has been shut down, reducing drug dosage. "In cancer therapy research, scientists are always interested in answering two questions: how to kill the cancer effectively and how to reduce the side effects of chemotherapeutic drugs," said Wan Mingxi, professor of biomedical engineering also at Xi'an Jiaotong University and corresponding author of the paper. "We have found that gas embolotherapy has the potential to successfully address both of these areas," said Wan.
Artificial intelligence the brains behind city's drive for better future
By Cao Yingying | China Daily | Updated: 2018-07-13 08:03 Xi'an Hi-Tech Industries Development Zone in Shaanxi province is focusing on artificial intelligence as part of efforts to develop as a science and technology city. Chinese AI company iFlytek signed an agreement with the zone in late May. According to the agreement, iFlytek will set up a research institution, an innovative entrepreneur platform and its Xi'an branch in the zone. The intelligent voice tech company will launch projects covering the education, medical and smart city sectors. Xi'an and iFlytek will also promote the automobile, robotics and tourism sectors based on the company's leading AI technologies and industry experience. "We hope Xi'an will become the main base for iFlytek professionals and will be the testing ground for iFlytek's latest AI technologies," Liu Qingfeng, chairman of the company, said at the signing ceremony. Xi'an Chishine Photoelectric Technology Co, founded in 2014, has developed many products related to 3D cameras and artificial intelligence, which have been applied in medical plastic surgery, facial recognition, 3D education and entertainment industries. According to Zhou Xiang, CEO of the company, it has developed 40 independent intellectual property rights and holds the world's largest 3D facial scan database. "In recent years, Xi'an Hi-Tech Industrial Development Zone has promoted the continuous development of high-end advanced technology, such as AI, and has strengthened the driving effects of the high-tech industry," Zhou said. The zone has released industry plans and supportive policies for AI and brought in abundant scientific research resources from Xi'an Jiaotong University and the Chinese Academy of Sciences' Xi'an Institute of Optics and Precision Mechanics, as well as other universities and colleges in Xi'an. The combination of industry and education has provided good fundamental conditions for development. "I am sure the AI industry in the zone will make more achievements even more quickly in the future," Zhou said. However, the zone still needs to improve the industrial chain of AI industry, according to the CEO. The suppliers of AI enterprises are mostly located in South China and East China, which has led to a sharp rise in logistics costs, Zhou added. In addition, the cooperation among AI enterprises and R&D are centered in the regions of Southeast China. Zhou said it has meant that AI enterprises have relatively few opportunities, which limits the progress of local AI players. Wang Shaofeng, CEO of Shaanxi Rocktech Co, a computer system solution provider, said local AI enterprises have many plans but fewer actual products, and often their research is not connected with market demand. AI is still an emerging industry, requiring experienced professionals and crossover personnel from both AI and traditional industries, he said. "AI has great development potential as it will be integrated with all aspects of daily life. We will explore more real life applications for AI, improve the range of the industry and meet the market demands," Wang said. Wang's company, founded in 2007, has set up its R&D center in Xi'an, and has sales and service agencies in Beijing, Shanghai, Shenzhen in Guangdong province and Chengdu in Sichuan province. caoyingying@chinadaily.com.cn
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1 XJTU began in Shanghai in 1896 as the Nanyang Public School through an imperial edict issued by the Guangxu Emperor, under the Business and Telegraphs Office of the imperial government.
2 XJTU's faculty and staff of more than 5500 includes twelve members of the Chinese National Academy of Engineering, nine of whom are also members of the Chinese National Academy of Sciences; 38 Changjiang (Yangtze River) Scholars; and 25 National Science Fund for Distinguished Young Scholars award winners.
3 XJTU began in Shanghai in 1896 as the Nanyang Public School through an imperial edict issued by the Guangxu Emperor, under the Business and Telegraphs Office of the imperial government.
4 XJTU's faculty and staff of more than 5500 includes twelve members of the Chinese National Academy of Engineering, nine of whom are also members of the Chinese National Academy of Sciences; 38 Changjiang (Yangtze River) Scholars; and 25 National Science Fund for Distinguished Young Scholars award winners.
5 Xi'an Jiaotong University (abbreviated XJTU) is a C9 League university with strengths in engineering, technology, management, and public health located in Xi'an, Shaanxi, China.
6 XJTU's faculty and staff of more than 5500 includes twelve members of the Chinese National Academy of Engineering, nine of whom are also members of the Chinese National Academy of Sciences; 38 Changjiang (Yangtze River) Scholars; and 25 National Science Fund for Distinguished Young Scholars award winners.
7 Xi'an Jiaotong University (abbreviated XJTU) is a C9 League university with strengths in engineering, technology, management, and public health located in Xi'an, Shaanxi, China.
8 XJTU began in Shanghai in 1896 as the Nanyang Public School through an imperial edict issued by the Guangxu Emperor, under the Business and Telegraphs Office of the imperial government.
9 Xi'an Jiaotong University (abbreviated XJTU) is a C9 League university with strengths in engineering, technology, management, and public health located in Xi'an, Shaanxi, China.
10 Xi'an Jiaotong University (abbreviated XJTU) is a C9 League university with strengths in engineering, technology, management, and public health located in Xi'an, Shaanxi, China.
11 XJTU's faculty and staff of more than 5500 includes twelve members of the Chinese National Academy of Engineering, nine of whom are also members of the Chinese National Academy of Sciences; 38 Changjiang (Yangtze River) Scholars; and 25 National Science Fund for Distinguished Young Scholars award winners.
12 XJTU began in Shanghai in 1896 as the Nanyang Public School through an imperial edict issued by the Guangxu Emperor, under the Business and Telegraphs Office of the imperial government.
13 XJTU's faculty and staff of more than 5500 includes twelve members of the Chinese National Academy of Engineering, nine of whom are also members of the Chinese National Academy of Sciences; 38 Changjiang (Yangtze River) Scholars; and 25 National Science Fund for Distinguished Young Scholars award winners.
14 XJTU began in Shanghai in 1896 as the Nanyang Public School through an imperial edict issued by the Guangxu Emperor, under the Business and Telegraphs Office of the imperial government.
15 Xi'an Jiaotong University (abbreviated XJTU) is a C9 League university with strengths in engineering, technology, management, and public health located in Xi'an, Shaanxi, China.